姓名 | 翟振亞 |
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職稱/職務 | 副研究員/副所長(聘用) | |
E-mail:
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電話: | 15813318526 |
研究領域:
1.腸道干細胞發育及腸道健康研究;
2.膽汁酸對細胞代謝的調控機制研究。
3.調控腸道健康和脂質代謝的藥食同源植物食品開發
教育經歷:
2010/09–2014/06,華南農業大學,動物科學學院,學士學位
2014/09 - 2019/06,華南農業大學,動物科學學院,博士學位 (導師:印遇龍 院士)
工作經歷
2023-至今 江西省科學院生物資源研究所 副研究員/副所長(聘用)
2020-2022 江西省科學院與中科院亞熱帶農業生態研究所聯合培養博士后
2019-2022 江西省科學院生物資源研究所 助理研究員
承擔及參與科研項目
[1] 國家自然科學基金(32360854)項目,2024-2027.(在研)
[2] 江西省主要學科帶頭人(青年項目,20232BCJ23049),2024-2026.(在研)
[3] 江西省自然科學基金青年基金(20232BAB215056),2024-2026.(在研)
[4] 中國博士后科學基金第68批面上項目資助(2020M682108),2020-2022.(結題)
[5] 江西省重點研發計劃一般項目(20203BBFL63054),2020-2022。(結題)
[6] 江西省科學院省級財政科研項目經費包干制試點示范項目(重點研發計劃-重點項目,2022YSBG21001),2022-2024(在研)
[7] 江西省科學院省級科研院基礎研究項目(2023YJC2001),2023-2024(在研)
[8] 國家自然科學基金項目(32260593)(排名第二,參與,在研)
代表性論著
[1] Zhai Z*, Liu Y, Niu K, Zeng W, Wang R, Guo X, Lin C, Hu L. Oleanolic acid alleviate intestinal inflammation by inhibiting Takeda G-coupled protein receptor (TGR) 5 mediated cell apoptosis. Food Funct. 2024 Feb 19;15(4):1963-1976. doi: 10.1039/d3fo04882a. PMID: 38275075.(第一/通訊作者,中科院1區,TOP期刊)
[2] Zhu M, Lin C, Niu K, Liu Y, Zeng W, Wang R, Guo X, Zhai Z*. Bile Acid Metabolic Profiles and Their Correlation with Intestinal Epithelial Cell Proliferation and Barrier Integrity in Suckling Piglets. Animals (Basel). 2024 Jan 17;14(2):287. doi: 10.3390/ani14020287. PMID: 38254456; PMCID: PMC10812516.(JCR 1區,IF=5.64)
[3] Liu Y, Niu K, Wang R, Liang X, Lin C, Wu X, Zhai Z*. Taurochenodeoxycholic acid inhibits intestinal epithelial cell proliferation and induces apoptosis independent of the farnesoid X receptor. Food Funct. 2023 Jun 6;14 (11):5277-5289. doi: 10.1039/d3fo00770g. PMID: 37195071. (通訊作者,中科院1區,TOP期刊)
[4] Zhai Z, Niu K M, Liu Y et al. The Gut Microbiota-Bile Acids-TGR5 Axis Mediates Eucommia ulmoides Leaf Extract Alleviation of Injury to Colonic Epithelium Integrity[J]. FRONT MICROBIOL, 2021,12:727681.(JCR 1區,IF=5.64)
[5] Zhai Z, Liu J, Niu K-M, Lin C, Tu Y, Liu Y, Cai L, Liu H and Ouyang K (2021) Integrated Metagenomics and Metabolomics to Reveal the Effects of Policosanol on Modulating the Gut Microbiota and Lipid Metabolism in Hyperlipidemic C57BL/6 Mice. FRONT. ENDOCRINOL. 12:722055. doi: 10.3389/fendo.2021.722055 (JCR1區,IF=5.55)
[6] Zhai Z, Niu K-M, Liu H et al. Policosanol alleviates hepatic lipid accumulation by regulating bile acids metabolism in C57BL6/mice through AMPK–FXR–TGR5 cross-talk. J. FODO SCI. 2021;1–13.DOI: 10.1111/1750-3841.15951(JCR2區,IF=3.167)
[7] Zhai Z, Zhang F, Cao R et al. Cecropin A Alleviates Inflammation Through Modulating the Gut Microbiota of C57BL/6 Mice With DSS-Induced IBD[J]. FRONT MICROBIOL, 2019,10(JCR1區,IF=4.32).
[8] Zhai Z, Ni X, Jin C et al. Cecropin A Modulates Tight Junction-Related Protein Expression and Enhances the Barrier Function of Porcine Intestinal Epithelial Cells by Suppressing the MEK/ERK Pathway[J]. INT J MOL SCI, 2018,19(7). (JCR1區,IF=3.6)
[9] 翟振亞, 胡小超, 高春起 等. 日糧添加二甲酸鉀和凝結芽孢桿菌對斷奶仔豬生長性能和免疫指標的影響[J]. 飼料工業, 2015,36(12):8-11.
[10] Chengquan T, Zhenya Z, Xiaojun N et al. Metabolomic Profiles Reveal Potential Factors that Correlate with Lactation Performance in Sow Milk[J]. SCI REP-UK, 2018,8(1).
[11] Chen J, Zhai Z, Long H et al. Inducible expression of defensins and cathelicidins by nutrients and associated regulatory mechanisms[J]. PEPTIDES, 2020,123.
[12] Ni X, Zhai Z, Xin Z et al. Antioxidant Properties and Transepithelial Transportation of Di-/tripeptides Derived from Simulated Gastrointestinal Digestion of Pig Blood Cells Hydrolysates[J]. eFood, 2020,1(3).
[13] Xin Z, Zhai Z, Long H et al. Metabolic Profiling by UPLC-Orbitrap-MS/MS of Liver from C57BL/6 Mice with DSS-Induced Inflammatory Bowel Disease[J]. Mediators Inflamm, 2020,2020:6020247.
[14] Fan H B, Zhai Z, Li X G et al. CDX2 Stimulates the Proliferation of Porcine Intestinal Epithelial Cells by Activating the mTORC1 and Wnt/beta-Catenin Signaling Pathways[J]. INT J MOL SCI, 2017,18(11).
[15] Li X, Zhu M, Chen M...Zhai Z et al. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/beta-catenin pathway[J]. TOXICOL LETT, 2019,305:19-31.
[16] Deng B, Ni X, Zhai Z et al. New Quantitative Structure-Activity Relationship Model for Angiotensin-Converting Enzyme Inhibitory Dipeptides Based on Integrated Descriptors[J]. J Agric Food Chem, 2017,65(44):9774-9781.
[17] 唐天悅, 翟振亞, 譚成全 等. 半胱胺在豬營養上的研究進展[J]. 動物營養學報, 2018,30(05):1647-1654.
[18] 金成龍, 翟振亞, 王丹 等. 甘氨酸銅替代硫酸銅對斷奶仔豬生長性能、血清生化參數和糞銅排放的影響[J]. 廣東農業科學, 2015,42(01):100-104.